Deficiency of the macrophage migration inhibitory factor gene has no significant effect on endotoxaemia

Macrophage Migration Inhibitory Factor

Macrophage Migration Inhibitory Factor Deficiency Augments Doxorubicin‐Induced Cardiomyopathy

BACKGROUND Recent evidence has depicted a role of macrophage migration inhibitory factor (MIF) in cardiac homeostasis under pathological conditions. This study was designed to evaluate the role of MIF in doxorubicin-induced cardiomyopathy and the underlying mechanism involved with a focus on autophagy. METHODS AND RESULTS Wild-type (WT) and MIF knockout (MIF(-/-)) mice were given saline or do...

Deficiency of Macrophage Migration Inhibitory Factor Gene Delays Bone Tendon Healing: A Biomechanical and Biological Study

Upregulation of macrophage migration inhibitory factor gene expression in stroke.

BACKGROUND AND PURPOSE MIF has been implicated to function in many inflammatory processes. This study examined whether MIF expression was affected in stroke and its underlying molecular mechanism. METHODS ELISA and qRT-PCR were used to detect MIF protein and mRNA in PBMCs from stroke patients, the ischemic rat brains, and controls. A MIF promoter assay under hypoxia was performed. RESULTS M...

Glucocorticoid Suppression of Macrophage Migration Inhibitory Factor

The ability of hydrocortisone to modify antigen-mediated inhibition of macrophage migration, an in vitro correlate of cellular immunity in the guinea pig, was investigated. Only the glucocorticoids, hydrocortisone and dexamethasone, significantly blocked migration inhibitory factor (MIF) activity in pharmacologic concentrations. Hydrocortisone had no effect on antigen "processing" by macrophage...